E for Ecstasy by Nicholas Saunders
Appendix 1: Reference Section

61 Use of MDMA to relieve symptoms in terminal cancer patients; phase one protocol, by Dr. Charles Grob. (Fax received 17/11/92)

This is a safety and tolerance study designed to determine the psychological and analgesic threshold level for MDMA. Six subjects in the health care industry will be chosen for these trials. They will take part in 3 experimental sessions separated by two to four weeks.

Each session will consist of oral administration of one capsule, which may be either 0.15mg/kg MDMA, 0.75mg/kg MDMA or a placebo. Grob predicts that 0.75 mg/kg will be the threshold dose.

Tests will be carried out on subjects' blood, psychological state, experience of physical pain and on neuropsychological effects.